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kamblek.appsci@coep.ac.in

Faculty

Dr. Ketaki Kamble

  • I am interested in exploring computational biology for answering persistent questions related to the emergent properties of neural networks like learning, memory and consciousness.

  • I also intend to explore strategies to enhance use of biocontrol agents for fungal infections in agricultural crops.

Department: 

Applied Science

Email: 

kamblek.appsci@coep.ac.in

Phone Number: 

+91-9850646472

Website: 

www.coep.org.in

User ID: 

421817118

Teaching Experience: 

1

Qualifications: 

  • Qualified the joint UGC-CSIR exam of National Eligibility Test (NET) for Lectureship (LS), with 53.2% and All India Rank 46. (June 2016)

  • Qualified Joint Admission Entrance exam for Integrated Ph. D at Indian Institute of Technology (IIT-JAM) with All India Rank 138. (June 2011)

  • Qualified all India entrance test for Jawaharlal Nehru University (JNU) with All India Rank 4. (June 2011)

  • First rank in first year, second year and third year in B. Sc. Biotech in BAMU.

 

Ph. D in Development and Genetics (2013-18) :

Muscle is a highly plastic tissue; that responds to neuromuscular activity, patho-physiological conditions, and exercise etc. predominantly by change of isoforms of sarcomeric as well as regulatory proteins. During my doctoral research, I addressed the question of how isoform transitions are regulated in response to development and/or environmental conditions. One of major strategies of isoform transition is by alternative splicing (AS). RNA binding proteins (RBPs) are key players of regulating AS. The objective of the study was to dissect the role of one such RBP, Ataxin 2 Binding Protein 1 (A2BP1) in isoform transitions, using muscles of Drosophila melanogaster as model system. Drosophila has two types of muscles- the tubular muscles (similar to vertebrate skeletal muscles) and the fibrilar muscles (similar to vertebrate cardiac muscles). We identified novel roles of A2BP1 in generation of muscle diversity during development. A2BP1 regulates muscle fiber-type specific isoform changes during development as a result of which structural protein stoichiometry is maintained in adult muscles. Rbfox1 mediates the specification of tubular muscle fibers by negatively regulating the determinants of fibrillar muscle fate, Extradenticle, Spalt (major) and Arrest, in tubular muscles. Conversely, negative regulation of Rbfox1 by Salm and/or Arrest is crucial to fibrillar muscle fate in the DLMs. It is responsible for conferring muscle fiber specific isoform of structural protein, Troponin-I, failure of which leads to a muscle hypercontraction phenotype in the DLMs.

 

MS (2011-2013):

As part of Integrated PhD program in IISc, I completed 64 credits in 4 semesters with total grade point average (TGPA) score of 6.3/8. The subjects studied as part of course work are- Biochemistry, Microbiology, Genetics, Laboratory techniques, Introduction to Biophysical Chemistry, Proteomics, Evolutionary Biology, Gene expression during Development, Protein structure, Folding and Design, Mathematics and statistics for biologists, RNA biology, Molecular and cellular biology, Current trends in Drug Discovery, Topics in Theoretical Biology, Quantitative Ecology, Science and Technology, Principles of Genetic Engineering

1. Ropalidia marginanta behaviour - Raghavendra Gadakar lab, Department of Ecological Science (CES), IISc.

2. Arabidopsis thaliana leaf growth - Utpal Nath lab, Department of Molecular and Cellular Biology (MCB), IISc

 

Teaching Responsibility: 

Courses-

 

  • Science of Living System (Credits 3:0)

  • Environmental Studies (Mandatory audit course)

Additional Responsibility: 

  • Mentorship First Year Engineering students

  • Organizing workshops/talks for students about health and lifestyle awareness.

Publications: 

  • Poster “Role of dA2BP1 in IFM development and function.” Kamble K., and Nongthomba U. Biennial Drosophila Research Conference, December 2015.

  • Poster “Roles of the dA2BP1 in maintaining structural protein stoichiometry and fiber diversity of Drosophila muscle” Kamble K., and Nongthomba U. 58th Annual Drosophila Research Conference, March-April 2017

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